Kavli Institute NeuroLunch
May 17th, 2016
Ho Sung Rhee, PhD (Wichterle Lab)
"Stage-specific recruitment of Isl1 reveals dynamic enhancer landscape in postmitotic motor neurons"
During my Ph.D. training in Frank Pugh’s lab, I developed a high-resolution mapping method for DNA-binding proteins, and revealed how chromatin structure is organized and genes are regulated by transcription factors at near nucleotide resolution. I am interested in genome-wide characterization of the regulatory circuitry that specifies and maintains cell identity during differentiation into postmitotic motor neurons.
It is currently unknown how genomic regulatory regions control gene expression programs to maintain cell identity in postmitotic neurons. We mapped genome-wide enhancer landscape of embryonic stem cells differentiating into spinal hypaxial motor neurons. Stable motor neuron expression programs are controlled by highly dynamic regulatory elements engaged by stage-specific transcriptional complexes.
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