Ann McDermott, PhD

Using the most recent nuclear magnetic resonance methods, the McDermott lab studies the structure, function, and conformational dynamics of proteins in native-like environments. Efforts of the research group demonstrated that NMR spectra of “solid state” proteins, such as membrane proteins in native lipid bilayers, or protein assemblies like viral coats, can serve as the basis for structural and dynamic investigations. NMR studies clarified the accordance of enzymatic function to protein conformational exchange, including active site loop motions and substrate repositioning.

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